K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum.
Toischer K, Lehnart S E, Tenderich G, Kaneko N et al
Basic Res Cardiol.2009 Aug:30,2009
Pharmacological characteristics and clinical applications of K201.
Kaneko N, Matsuda R, Hata Y, Shimamoto K.
Current clinical pharmacology 2009 May;4(2):126-131.
New 1,4-benzothiazepine derivative, K201, demonstrates cardioprotective effects against sudden cardiac cell death and intracellular calcium blocking action
Drug Development Research Volume 33, Issue 4, Date: December 1994, Pages: 429-438
Crystal structure of annexin V with its ligand K-201 as a calcium channel activity inhibitor
Noboru Kaneko, Hideo Ago, Ryuko Matsuda, Eiji Inagaki, Masashi Miyano
Journal of Molecular Biology, Volume 274, Issue 1, 21 November 1997, Pages 16-20
Inhibition of annexin V-dependent Ca2+ movement in large unilamellar vesicles by K201, a new 1,4-benzothiazepine derivative
Noboru Kaneko, Ryuko Matsuda, Masashi Toda, Ken Shimamoto
Biochimica et Biophysica Acta (BBA) - Biomembranes, Volume 1330, Issue 1, 13 November 1997, Pages 1-7
K201, a multi-channel blocker, inhibits clofilium-induced torsades de pointes and attenuates an increase in repolarization
Hisashi Hasumi, Ryuko Matsuda, Ken Shimamoto, Yoshihito Hata, Noboru Kaneko
European Journal of Pharmacology, Volume 555, Issue 1, 19 January 2007, Pages 54-60.
Norepinephrine-induced diastolic dysfunction with aortic valve opening under calcium-loading in rats
Noboru Kaneko, Ry uko Matsuda, Takahide Nakajima, Makoto Shinozaki, Naoyuki Ohtani, Kazuhiko Oda, Hisashi Hasumi, Ken Shimamoto
Drug Development Research Volume 67, Issue 6, Date: June 2006, Pages: 511-518
K201 Improves norepinephrine-induced diastolic dysfunction with preserved ejection fraction
Noboru Kaneko, Ryuko Matsuda, Naoyuki Ohtani, Takahide Nakajima, Takuo Arikawa, Hidehiko Suzuki, Shigeru Toyoda, Migaku Kikuchi, Yoshihito Hata, Shichiro Abe, Isao Taguchi, Ken Shimamoto
Drug Development Research Volume 67, Issue 11, Date: November 2006, Pages: 852-861
Effects of Novel 1,4-Benzothiazepine Derivative, K201, on Cytosolic Ca2+ and Contraction in Isolated Smooth Muscle of Rat Aorta
Shimamoto Ken, Kaneko Noboru
Tokyo Joshi Ikadaigaku Zasshi 74(1) 39-46,2004
Protective effect of JTV519 on prolonged myocardial preservation
M. Hachida, H. Lu, N. Kaneko, M. Nonoyama, H. Koyanagi
Transplantation Proceedings, Volume 31, Issues 1-2, 3 February 1999, Page 1094
Significant effect of 1,4-benzothiazepine derivative (K2) in improving myocardial preservation
M. Hachida, N. Kaneko, A. Ohkado, H. Hoshi, M. Nonoyama, S. Saitou, Y. Bonkohara, N. Hanayama, M. Miyagishima, H. Koyanagi
Transplantation Proceedings Volume 29, Issues 1-2, February-March 1997, Pages 1346-1348
Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts
H Tateishi, M Yano, M Mochizuki, T Suetomi, M Ono, X Xu, H Uchinoumi, S Okuda, T Oda, S Kobayashi, T Yamamoto, Y Ikeda, T Ohkusa, N Ikemoto, M Matsuzaki
Cardiovasc Res. 2008 Dec 2.,2008
Identification of Target Domains of the Cardiac Ryanodine Receptor to Correct Channel Disorder in Failing Hearts
Takeshi Yamamoto, Masafumi Yano, XiaoJuan Xu, Hitoshi Uchinoumi, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shigeki Kobayashi, Noriaki Ikemoto, and Masunori Matsuzaki
Circulation 117: 762 - 772, 2008