関連文献
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Kaneko N, Loughrey CM, Smith GL, et al. A novel ryanodine receptor 2 inhibitor, M201-A, enhances natriuresis, renal function and lusi-inotropic actions: Preclinical and phase I study. Br. J. Pharmacol., Published online 2024. DOI: 10.1111/bph.16379
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Park SJ, Kim Y, Yang SM, et al. Discovery of endoplasmic reticulum calcium stabilizers to rescue ER-stressed podocytes in nephrotic syndrome. Proc Natl Acad Sci. 2019;116(28):14154-14163. doi:10.1073/pnas.1813580116
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Darcy YL, Diaz-Sylvester PL, Copello JA. K201 (JTV519) is a Ca2+-Dependent Blocker of SERCA and a Partial Agonist of Ryanodine Receptors in Striated Muscle. Mol Pharmacol. 2016;90(2):106. doi:10.1124/mol.115.102277
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Otani N, Matsuda R, Oda K, Nishino S, Inoue T, Kaneko N. Protective effect of K201 on isoproterenol-induced and ischemic-reperfusion-induced ventricular arrhythmias in the rat: comparison with diltiazem. J Cardiovasc Pharmacol Ther. 2013;18(2):184-190. doi:10.1177/1074248412465489
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Kelly A, Elliott EB, Matsuda R, Kaneko N, Smith GL, Loughrey CM. The effect of K201 on isolated working rabbit heart mechanical function during pharmacologically induced Ca2+ overload. Br J Pharmacol. 2012;165(4b):1068-1083. doi:10.1111/j.1476-5381.2011.01531.x
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Elliott EB, Hasumi H, Otani N, et al. K201 (JTV-519) alters the spatiotemporal properties of diastolic Ca2+ release and the associated diastolic contraction during β-adrenergic stimulation in rat ventricular cardiomyocytes. Basic Res Cardiol. 2011;106(6):1009-1022. doi:10.1007/s00395-011-0218-4
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Loughrey CM, Otani N, Seidler T, et al. K201 modulates excitation-contraction coupling and spontaneous Ca2+ release in normal adult rabbit ventricular cardiomyocytes. Cardiovasc Res. 2007;76(2):236-246. doi:10.1016/j.cardiores.2007.06.014
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Hasumi H, Matsuda R, Shimamoto K, Hata Y, Kaneko N. K201, a multi-channel blocker, inhibits clofilium-induced torsades de pointes and attenuates an increase in repolarization. Eur J Pharmacol. 2007;555(1):54-60. doi:10.1016/j.ejphar.2006.10.005
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Kumagai K, Nakashima H, Gondo N, Saku K. Antiarrhythmic effects of JTV-519, a novel cardioprotective drug, on atrial fibrillation/flutter in a canine sterile pericarditis model. J Cardiovasc Electrophysiol. 2003;14(8):880-884. doi:10.1046/j.1540-8167.2003.03050.x
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Kaneko N, Matsuda R, Toda M, Shimamoto K. Three-dimensional reconstruction of the human capillary network and the intramyocardial micronecrosis. Am J Physiol-Heart Circ Physiol. 2011;300(3):H754-H761. doi:10.1152/ajpheart.00486.2010